Previous studies suggest that infants of Mexican immigrants have favor
able birth outcomes despite their high socioeconomic risks. These favo
rable outcomes have been associated with a protective sociocultural or
ientation among immigrants. A sample of 708 infants of Mexican origin
was assessed to determine whether such health advantages at birth are
sustained at 8 to 16 months of age, or alternatively, whether their he
alth deteriorates because of adverse socioeconomic conditions. A a cro
ss-sectional survey was conducted in San Diego County to determine whe
ther the child was healthy or ill (the latter indicating a history of
serious infectious disease) and the factors associated with this outco
me. Among infants born without serious medical problems, 74% remained
healthy. For 26% of the infants, their health status was eroded by soc
ial conditions. Factors associated with illness were large households,
barriers to care, and maternal characteristics including smoking, pre
gnancy complications, and employment. Women born in Mexico who were ne
wcomers to the United States and spoke Spanish exclusively were more l
ikely than non-newcomers to have ill children. In this population, one
fourth of Latino infants of immigrants were at high risk for serious
infectious disease despite using preventive care.