CYTOGENETICS OF TUMORS OF SOFT-TISSUE AND BONE - IMPLICATION FOR PATHOLOGY

Pathologists should be aware of the existence of diagnostically useful chromosomal rearrangements in several soft tissue and bone tumors. Th ey include rearrangement of 8q12 in lipoblastomas, ring chromosomes in atypical lipomas, ring and giant marker chromosomes in well different iated liposarcomas, t(12;16)(q13;p11) in myxoid liposarcomas, rearrang ement of 7p21-22 in low-grade endometrial stromal sarcomas, t(2;13)(q3 7;q14) in alveolar rhabdomyosarcomas, t(X;18)(p11.2;q11.2) in synovial sarcomas, t(12;22) (q13;q13) in clear cell sarcomas, t(11;22)(q24;q12 ) in Ewing's sarcomas and peripheral neuroepitheliomas, and t(9;22)(q2 1-31;q11-12) in extraskeletal myxoid chondrosarcomas.