AMPLIFICATION OF CHROMOSOME SUBREGION 12P11.2-P12.1 IN A METASTASIS OF AN I(12P)-NEGATIVE SEMINOMA - RELATIONSHIP TO TUMOR PROGRESSION

Authors
SUIJKERBUIJK RF SINKE RJ WEGHUIS DEMO ROQUE L FORUS A STELLINK F SIEPMAN A VANDEKAA C SOARES J VANKESSEL AG
Citation
Rf. Suijkerbuijk et al., AMPLIFICATION OF CHROMOSOME SUBREGION 12P11.2-P12.1 IN A METASTASIS OF AN I(12P)-NEGATIVE SEMINOMA - RELATIONSHIP TO TUMOR PROGRESSION, Cancer genetics and cytogenetics, 78(2), 1994, pp. 145-152
Citations number
33
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
78
Issue
2
Year of publication
1994
Pages
145 - 152
Database
ISI
SICI code
0165-4608(1994)78:2<145:AOCS1I>2.0.ZU;2-H
Abstract
Cytogenetic analysis of a metastasis of a human testicular germ cell t umor (seminoma) revealed multiple numerical and structural anomalies, including an abnormally banding region (ABR) present on the short arm of one of the chromosome 12 homologs. Fluorescence in situ- and compar ative genomic hybridization experiments revealed that the ABR results from the amplification of 12p11.2-p12.1 derived sequences. We speculat e that this particular region may harbor gene(s) relevant for testicul ar germ cell tumor progression.