PERICENTRIC-INVERSION (2)(P15Q35) IN AN ALVEOLAR RHABDOMYOSARCOMA

We report a 7-year-old girl with a pericentric inversion of chromosome 2, inv(2)(p15q35), in a ''solid variant'' of alveolar rhabdomyosarcom a. The breakpoint in the long arm of chromosome 2 at band q35 is, at t he cytogenetic level, identical to the breakpoint observed in the well -established reciprocal t(2;13)(q35;q14) associated with the alveolar subtype of rhabdomyosarcoma. In this case, however, no reciprocal tran slocation has occurred with chromosome 13 or any other chromosome, sug gesting that the single critical breakpoint in alveolar rhabdomyosarco ma may be located at 2q35.