ALCOHOLICS WITH REDUCED DOPAMINE D-2 RECEPTOR FUNCTION POSSESS NORMALPLATELET MONOAMINE-OXIDASE ACTIVITY

Authors
BALLDIN J BERGGREN U LINDSTEDT G ORELAND L
Citation
J. Balldin et al., ALCOHOLICS WITH REDUCED DOPAMINE D-2 RECEPTOR FUNCTION POSSESS NORMALPLATELET MONOAMINE-OXIDASE ACTIVITY, Alcohol and alcoholism, 29(6), 1994, pp. 659-661
Citations number
11
Categorie Soggetti
Substance Abuse
Journal title
Alcohol and alcoholism → ACNP
ISSN journal
07350414
Volume
29
Issue
6
Year of publication
1994
Pages
659 - 661
Database
ISI
SICI code
0735-0414(1994)29:6<659:AWRDDR>2.0.ZU;2-J
Abstract
Platelet monoamine oxidase (MAO) activity, proposed to be a marker for central 5-hydroxytryptamine (5-HT) capacity, was investigated in 14 s everely alcohol-dependent subjects with reduced dopamine (DA) D-2 rece ptor function, as assessed by the growth hormone responses to apomorph ine. Twelve healthy men were used as controls. Platelet MAO activity i n the alcohol-dependent subjects was not different from that in contro ls. The finding from this preliminary study suggests that severely alc ohol-dependent subjects with reduced DA D-2 receptor function have nor mal 5-HT capacity.