A STUDY OF THE ASSOCIATION OF ALCOHOLISM WITH A1A2BO AND MNSS POLYMORPHISMS

Polymorphic variants of A1A2B0 and MNSs systems were analysed in a sam ple of 300 alcoholic patients subdivided according to gender and famil y history of alcoholism. There was agreement between observed and expe cted frequencies assuming genetic equilibrium. No association between phenotypes or genes of the A1A2B0 polymorphism and alcoholism was foun d when the Woolf method was used to evaluate possible associations. In the MNSs polymorphism, when the Woolf method was applied, significant values of chi(2) suggest a possible association between alcoholism an d this blood marker, but after Bonferroni correction this association was rejected.