SYRINGOLYMPHOID HYPERPLASIA WITH ALOPECIA

Syringolymphoid hyperplasia with alopecia is an uncommon skin disorder described in 1969 by Sarkany. Since then only three additional cases have been reported, all in the European literature. We present a 59-ye ar-old man with two persistent hyperpigmented hairless patches of 13 y ears duration. Biopsy specimens revealed characteristic hyperplastic c hanges of the eccrine glands and ducts and a dense lymphocytic infiltr ate surrounding eccrine structures with ''syringotropism''. Perifollic ular lymphocytic infiltration and changes consistent with follicular m ucinosis and mycosis fungoides were also present. Imunophenotyping and gene rearrangement studies showed the cells to be primarily of the T helper phenotype with rearrangement of the surface receptor gene.