We report a case of sclerosing B-cell lymphoma involving the skin. The
patient is a 43-year-old man who came to our institution with a 4-yea
r history of multinodular masses in the back. A thoracic CT scan demon
strated subcutaneous masses with extension to the posterior parietal p
leura and compression of several epidural spaces. An incisional biopsy
was performed and demonstrated an infiltrative process in the lower d
ermis composed of interconnected thick sclerosing bands forming compar
tments around groups of large neoplastic cells. These neoplastic cells
were shown to be B lymphocytes using immunohistochemical stains. A di
agnosis of diffuse sclerosing B-cell lymphoma, large cell type, was ma
de. Our case is reported to alert dermatologists and dermatopathologis
ts to the occurrence of this neoplasm in the skin which could be confu
sed with a deep inflammatory process or other neoplastic conditions.