SYNTHESIS AND ANTIACETYLCHOLINESTERASE ACTIVITY OF THIAPHYSOSTIGMINE DERIVATIVES

Authors
ANNAKA M YASUDA K YAMADA M KAWAI A TAKAMURA N SUGASAWA S MATSUOKA Y IWATA H FUKUSHIMA T
Citation
M. Annaka et al., SYNTHESIS AND ANTIACETYLCHOLINESTERASE ACTIVITY OF THIAPHYSOSTIGMINE DERIVATIVES, Heterocycles, 39(1), 1994, pp. 251-270
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
39
Issue
1
Year of publication
1994
Pages
251 - 270
Database
ISI
SICI code
0385-5414(1994)39:1<251:SAAAOT>2.0.ZU;2-8
Abstract
A series of thiaphysostigmine derivatives (2a, b and 3a, b), with a su lfur atom instead of N-methyl group in B ring or C ring of physostigmi ne (1), were synthesized, and their inhibitory effects on AChE and BuC hE activity, and acute toxicity were evaluated.