With the aim of obtaining a porphyrin derivative useful for diagnosis
and therapy of cancer, fluorinated analogs of hematoporphyrin, which h
ad a trifluorohydroxyethyl group in the place of one of the hydroxyeth
yl groups, were synthesized by acetylation of trifluorohydroxyethyldeu
teroporphyrin dimethyl esters, followed by reduction of the acetyl gro
up.