LEG BONE PAIN SYNDROME DUE TO CYCLOSPORINE IN A RENAL-TRANSPLANT PATIENT

A leg bone pain syndrome of unclear etiology has been recently describ ed in renal transplant patients receiving cyclosporine A. Herein we re port a 54-year-old woman treated with cyclosporine A (CsA), corticoste roids and azathioprine who developed two months after renal transplant ation severe symmetric pain with periarticular soft tissue swelling in the knees and metatarsophalangeal joints. Scintigraphy showed periart icular radionuclide activity. Clinical onset was associated with both the high dosage and with the plasma levels of CsA. Symptoms improved w hen the dosage of CsA was reduced and the plasma levels declined to le ss than 150 ng/ml.