GENOMIC EFFECTS OF TAMOXIFEN

Tamoxifen exerts a variety of genomic effects which explains, in part, its efficacy in both hormone-responsive and independent tumours. The above quotation expresses this in a timeless and elegant way: our unde rstanding of antiestrogen action has been narrowly fettered by the sim plistic interpretation of this drug as an antihormone. The regulatory and controlling influence of Tamoxifen on numerous genes involved in a poptosis (p53, Bcl 2, c-myc, erb-B2 and others) will be discussed in t his review.