POTENTIAL ANTITUMOR AGENTS .25. SYNTHESIS AND CYTOTOXIC ACTIVITY OF -CHLORO-3-INDOLYLMETHYLENE)1,3-DIHYDROINDOL-2-ONES

Authors
ANDREANI A LOCATELLI A RAMBALDI M LEONI A BOSSA R FRACCARI A GALATULAS I
Citation
A. Andreani et al., POTENTIAL ANTITUMOR AGENTS .25. SYNTHESIS AND CYTOTOXIC ACTIVITY OF -CHLORO-3-INDOLYLMETHYLENE)1,3-DIHYDROINDOL-2-ONES, Anticancer research, 16(6B), 1996, pp. 3585-3588
Citations number
15
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
16
Issue
6B
Year of publication
1996
Pages
3585 - 3588
Database
ISI
SICI code
0250-7005(1996)16:6B<3585:PAA.SA>2.0.ZU;2-J
Abstract
The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehy des gave chloro-3-indolylmethylene)-1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures of HeLa cells. 2-Chl oro derivatives with at least one unsubstituted NH group, are promisin g candidates for further investigation.