TOWARDS UNDERSTANDING LAMIN GENE-REGULATION

The lamins are components of the nuclear lamina, which forms a fibrous meshwork lining the inner nuclear membrane. Lamina-membrane interacti ons play a crucial role during nuclear disassembly and reassembly at m itosis, whereas lamina-chromatin association has been proposed to be e ssential for chromatin organization. The composition of the lamina cha nges considerably during embryonic development and cell differentiatio n. Recent studies have provided insights into the regulation of the la min genes.