DISTRIBUTION OF PLATINUM IN HUMAN GYNECOLOGIC TISSUES AND LYMPH-NODESAFTER INTRAVENOUS AND INTRAARTERIAL NEOADJUVANT CHEMOTHERAPY

Fourteen patients with ovarian and cervical cancer were treated with p latinum drug-based intravenous and intraarterial neoadjuvant chemother apy, respectively, followed by reductive surgery. Platinum accumulatio n in tissues was assayed to compare the distribution of platinum in ca ncer tissues, myometrium, ovary, and pelvic lymph node following intra venous and intraarterial administration. Platinum accumulation was hig her in the cancer tissue and in the myometrium than in the ovary and t he lymph nodes after the intraarterial neoadjuvant chemotherapy. The l evel of platinum accumulation in tissues to that in the cancer tissues was calculated and compared between the two groups. The level of plat inum accumulation in the lymph node to that in the cancer tissue was s ignificantly higher in the intravenous that in the intraarterial group . Furthermore, the relative platinum accumulation was calculated from the total dosage of cisplatin administered. The relative platinum accu mulation in the cancer tissue and the myometrium was significantly hig her in the intraarterial than in the intravenous group. However, there were no significant differences in the lymph nodes. These findings su ggest that intraarterial neoadjuvant chemotherapy should be effective on advanced cervical cancer.