ON THE REGIOCHEMISTRY OF THE ALKYLATION OF TERT-BUTYL -BUTYL-1,2-DIHYDRO-2-OXO-3-PYRIDYLMETHYL]CARBAMATE - PRECURSOR OF A SERIES OF POTENT ANGIOTENSIN-II RECEPTOR ANTAGONISTS

Authors
KOPPE T MEDERSKI WWKR OSSWALD M SCHWARZ M
Citation
T. Koppe et al., ON THE REGIOCHEMISTRY OF THE ALKYLATION OF TERT-BUTYL -BUTYL-1,2-DIHYDRO-2-OXO-3-PYRIDYLMETHYL]CARBAMATE - PRECURSOR OF A SERIES OF POTENT ANGIOTENSIN-II RECEPTOR ANTAGONISTS, Tetrahedron letters, 36(3), 1995, pp. 377-380
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
3
Year of publication
1995
Pages
377 - 380
Database
ISI
SICI code
0040-4039(1995)36:3<377:OTROTA>2.0.ZU;2-V
Abstract
The key intermediate 5 of a large number of potent AT(1) selective ang iotensin II antagonists e.g. the potent cyclopropylmethyl derivative 1 (EMD 69943) was synthesized by regioselective alkylation of carbamate 3 with the well-known 4'-(bromomethyl)biphenyl-2-carbonitrile (4) and n-butyllithium as the preferred base.