A GENERAL-METHOD FOR THE SYNTHESIS OF PEPTIDYL SUBSTRATES FOR PROTEOLYTIC-ENZYMES

Authors
WHITMORE AJ DANIEL RM PETACH HH
Citation
Aj. Whitmore et al., A GENERAL-METHOD FOR THE SYNTHESIS OF PEPTIDYL SUBSTRATES FOR PROTEOLYTIC-ENZYMES, Tetrahedron letters, 36(3), 1995, pp. 475-476
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
3
Year of publication
1995
Pages
475 - 476
Database
ISI
SICI code
0040-4039(1995)36:3<475:AGFTSO>2.0.ZU;2-4
Abstract
The synthesis of an heterogeneous peptide substrate for the assay of p roteases was carried out by cleaving a protein using a protease to gen erate small peptides which were then coupled to a chromophore, p-nitro aniline. The chromophoric peptide product could be used to assay for t he protease which produced the original peptides.