GLUCOCORTICOID-INDUCED DOWN-REGULATION OF TRANSFORMING GROWTH-FACTOR-BETA-1 IN ADULT-RAT LUNG FIBROBLASTS

Authors
SHULL S MEISLER N ABSHER M PHAN S CUTRONEO K
Citation
S. Shull et al., GLUCOCORTICOID-INDUCED DOWN-REGULATION OF TRANSFORMING GROWTH-FACTOR-BETA-1 IN ADULT-RAT LUNG FIBROBLASTS, Lung, 173(2), 1995, pp. 71-78
Citations number
28
Categorie Soggetti
Respiratory System
Journal title
Lung → ACNP
ISSN journal
03412040
Volume
173
Issue
2
Year of publication
1995
Pages
71 - 78
Database
ISI
SICI code
0341-2040(1995)173:2<71:GDOTG>2.0.ZU;2-B
Abstract
Transforming growth factor-beta 1 mRNA and transforming growth factor beta activity are decreased with exposure of normal adult rat lung fib roblasts to dexamethasone. Dexamethasone caused a decrease in transfor ming growth factor-beta 1 mRNA within 2 hours, which was sustained at least over a 24-hour period. The decrease in transforming growth facto r-beta 1 mRNA was dose related. Dexamethasone treatment of rat lung fi broblasts also resulted in a decrease of transforming growth factor be ta activity as determined by the mink lung cell growth inhibition assa y. These data indicate that glucocorticoids may regulate collagen synt hesis at least in part through the mediation of transforming growth fa ctor-beta 1 rat lung fibroblasts.