Partial meniscectomies were performed on 32 fresh human meniscal autop
sy specimens. The following laser systems were tested: carbon dioxide
(CO2), neodymium:yttrium aluminum garnet (Nd:YAG), potassium titanyl p
hosphate (KTP), holmium:YAG (Ho:YAG), and excimer. Meniscectomies with
these lasers were compared with scalpel, mechanical, and electrocaute
ry meniscectomies. Lasers were applied to specimens in and out of norm
al saline. Routine hematoxylin and eosin and sirius red sections were
prepared for each specimen, and the depths of thermal changes were ana
lyzed. Scanning electron microscopy was used to visualize the meniscec
tomy interface. Among these specimens, the scalpel and mechanical meni
scectomies showed the least extension of cellular changes (range, 10-1
5 mm). The excimer laser caused the least tissue changes of the lasers
tested. Tissue changes were less extensive with the pulsed CO2 laser
than with the holmium:YAG, neodymium:YAG, and KTP lasers. Scanning ele
ctron microscopy showed that use of the scalpel meniscectomy resulted
in the smoothest meniscectomy edge, followed by use of the excimer, CO
2, holmium:YAG, neodymium:YAG, and KTP lasers. The most surface disrup
tion occurred with electrocautery. Meniscectomies under saline require
d more energy and took longer in each case, with the holmium:YAG, neod
ymium:YAG, and CO2 laser cutting the best. Saline meniscectomies showe
d less thermal change. The COL and KTP lasers cut best in air.