INDUCTION OF PROTECTIVE CYTOTOXIC T-CELLS TO MURINE CYTOMEGALOVIRUS BY USING A NONAPEPTIDE AND A HUMAN-COMPATIBLE ADJUVANT (MONTANIDE ISA-720)

Authors
SCALZO AA ELLIOTT SL COX J GARDNER J MOSS DJ SUHRBIER A
Citation
Aa. Scalzo et al., INDUCTION OF PROTECTIVE CYTOTOXIC T-CELLS TO MURINE CYTOMEGALOVIRUS BY USING A NONAPEPTIDE AND A HUMAN-COMPATIBLE ADJUVANT (MONTANIDE ISA-720), Journal of virology, 69(2), 1995, pp. 1306-1309
Citations number
37
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
69
Issue
2
Year of publication
1995
Pages
1306 - 1309
Database
ISI
SICI code
0022-538X(1995)69:2<1306:IOPCTT>2.0.ZU;2-G
Abstract
The use of synthetic peptides representing cytotoxic T-cell (CTL) epit opes for human vaccination requires the identification of a suitable a djuvant formulation. A single immunization,vith Montanide ISA720/tetan us toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.