Aa. Scalzo et al., INDUCTION OF PROTECTIVE CYTOTOXIC T-CELLS TO MURINE CYTOMEGALOVIRUS BY USING A NONAPEPTIDE AND A HUMAN-COMPATIBLE ADJUVANT (MONTANIDE ISA-720), Journal of virology, 69(2), 1995, pp. 1306-1309
The use of synthetic peptides representing cytotoxic T-cell (CTL) epit
opes for human vaccination requires the identification of a suitable a
djuvant formulation. A single immunization,vith Montanide ISA720/tetan
us toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and
induced epitope-specific CTL. Such formulations will find application
in peptide-based CTL anti-viral vaccines.