SIMIAN IMMUNODEFICIENCY VIRUS SIVMAC CHIMERIC VIRUS WHOSE ENV GENE WAS DERIVED FROM SIV-ENCEPHALITIC BRAIN IS MACROPHAGE-TROPIC BUT NOT NEUROVIRULENT

Authors
JOAG SV STEPHENS EB GALBREATH D ZHU GW LI Z FORESMAN L ZHAO LJ PINSON DM NARAYAN O
Citation
Sv. Joag et al., SIMIAN IMMUNODEFICIENCY VIRUS SIVMAC CHIMERIC VIRUS WHOSE ENV GENE WAS DERIVED FROM SIV-ENCEPHALITIC BRAIN IS MACROPHAGE-TROPIC BUT NOT NEUROVIRULENT, Journal of virology, 69(2), 1995, pp. 1367-1369
Citations number
16
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
69
Issue
2
Year of publication
1995
Pages
1367 - 1369
Database
ISI
SICI code
0022-538X(1995)69:2<1367:SIVSCV>2.0.ZU;2-#
Abstract
We inoculated four rhesus macaques with molecularly cloned simian immu nodeficiency virus SIV(mac)239/17E env, a chimeric virus whose env gen e was derived from the brain of an SIV-encephalitic macaque. Blood and lymphoid tissues had high frequencies of infected cells. The virus wa s neuroinvasive, but productive virus replication did not occur in the brain, and animals did not develop encephalitis.