Oh. Clark et T. Hoelting, MANAGEMENT OF PATIENTS WITH DIFFERENTIATED THYROID-CANCER WHO HAVE POSITIVE SERUM THYROGLOBULIN LEVELS AND NEGATIVE RADIOIODINE SCANS, Thyroid, 4(4), 1994, pp. 501-505
Most current evidence suggests that patients with papillary or follicu
lar thyroid cancer after total thyroidectomy who are Tg positive (Tg g
reater than or equal to 10 ng/mL) and radioactive iodine scan negative
warrant treatment with 100 mCi of I-131 With a follow up scan and Tg
determination. If isolated focal metastatic deposits are present they
should be resected before treatment with radioiodine. Although some ph
ysicians might recommend radioiodine treatment only for high risk pati
ents, we would recommend it for all patients with elevated serum Tg le
vels that increase after TSH stimulation, or until further information
becomes available to support a different approach.