STRUCTURE OF MICROCIN C51, A NEW ANTIBIOTIC WITH A BROAD-SPECTRUM OF ACTIVITY

Authors
METLITSKAYA AZ KATRUKHA GS SHASHKOV AS ZAITSEV DA EGOROV TA KHMEL IA
Citation
Az. Metlitskaya et al., STRUCTURE OF MICROCIN C51, A NEW ANTIBIOTIC WITH A BROAD-SPECTRUM OF ACTIVITY, FEBS letters, 357(3), 1995, pp. 235-238
Citations number
14
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
357
Issue
3
Year of publication
1995
Pages
235 - 238
Database
ISI
SICI code
0014-5793(1995)357:3<235:SOMCAN>2.0.ZU;2-O
Abstract
The structure of microcin C51, a new antibiotic produced by E. coli, h as been determined. This antibiotic was shown to be a 1.18 kDa nucleot ide peptide. It consists of a heptapeptide with formylmethionine as th e N-terminus and a C-terminal asparagine linked with nebularin-5'-mono phosphate through the three-methylene bridge. The OH-group of threonin e is substituted. The peptide chain of microcin C51 synthesized on rib osomes is the longest among the known biologically active nucleotide p eptides.