DIVERSITY OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS - LESSONS FROM BEHAVIOR AND IMPLICATIONS FOR CNS THERAPEUTICS

Citation
Mw. Decker et al., DIVERSITY OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS - LESSONS FROM BEHAVIOR AND IMPLICATIONS FOR CNS THERAPEUTICS, Life sciences, 56(8), 1995, pp. 545-570
Citations number
151
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
ISSN journal
00243205
Volume
56
Issue
8
Year of publication
1995
Pages
545 - 570
Database
ISI
SICI code
0024-3205(1995)56:8<545:DONNA->2.0.ZU;2-7
Abstract
Although the molecular biology of neuronal nicotinic acetylcholine rec eptors (nAChRs) provides evidence for multiple receptor subtypes, few selective pharmacological tools exist to identify these subtypes in vi vo. However, the diversity of behavioral effects of available nAChR ag onists and antagonists reviewed in this paper suggests that neuronal n AChR subtypes may play distinct roles in a variety of behavioral outco mes. Further characterization of the behavioral effects of the activat ion of discrete nAChR subtypes may eventually provide information usef ul in designing selective nAChR ligands targeting a variety of CNS dis orders.