Mw. Decker et al., DIVERSITY OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS - LESSONS FROM BEHAVIOR AND IMPLICATIONS FOR CNS THERAPEUTICS, Life sciences, 56(8), 1995, pp. 545-570
Citations number
151
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Although the molecular biology of neuronal nicotinic acetylcholine rec
eptors (nAChRs) provides evidence for multiple receptor subtypes, few
selective pharmacological tools exist to identify these subtypes in vi
vo. However, the diversity of behavioral effects of available nAChR ag
onists and antagonists reviewed in this paper suggests that neuronal n
AChR subtypes may play distinct roles in a variety of behavioral outco
mes. Further characterization of the behavioral effects of the activat
ion of discrete nAChR subtypes may eventually provide information usef
ul in designing selective nAChR ligands targeting a variety of CNS dis
orders.