D. Laurier et al., ESTIMATION OF CHD RISK IN A FRENCH WORKING POPULATION USING A MODIFIED FRAMINGHAM MODEL, Journal of clinical epidemiology, 47(12), 1994, pp. 1353-1364
Citations number
24
Categorie Soggetti
Public, Environmental & Occupation Heath","Medicine, General & Internal
We adapt a recent model from the Framingham study (Circulation 1991; 8
3: 356-362) to predict CHD in France for both sexes over a large age r
ange. Calculations were based on data from the French PCV-METRA study.
In France, the Paris Prospective Study model could predict CHD but on
ly for men aged 43-53 years. Applied to men 43-53 years from the PCV-M
ETRA, the Framingham model estimated a 5-year CHD risk (4%) lower than
the risk reported in the Framingham sample, but significantly higher
than the risk estimated by the French model (2%). Differences in estim
ated CHD risk between the Framingham and the PCV-METRA samples were ex
plained for only 30% by adjustment on major CHD risk factors (mainly H
DL-cholesterol and tobacco). Modifying the intercept in the Framingham
model, agreement with estimated risk by the French model was improved
from 29 to 80%. By an appropriate change of the intercept, the Framin
gham model might be used to estimate CHD risk in other populations.