Background: The authors report the postoperative development of iris r
etraction syndrome in two individuals. This is a rare syndrome that ca
n present with pupillary block after an unrepaired rhegmatogenous reti
nal detachment. Patients: The authors report two patients who had the
iris retraction syndrome shortly after intraocular surgery. One patien
t had pupillary block that developed 6 months after cataract extractio
n and posterior chamber intraocular lens implantation. A second patien
t had uveitis, hypotony, and pupillary seclusion 4 weeks after pars pl
ana vitrectomy. Results: Both patients were treated successfully with
a scleral buckling procedure and peripheral iridectomy. Conclusion: Po
stoperative uveitis that occurs with iris retraction and pupillary sec
lusion should alert the physician of an occult retinal detachment and
warrant a thorough dilated funduscopic examination. Features unique to
this report include the development of iris retraction syndrome in th
e presence of a pseudophakos, the rapidity of onset of this disorder a
fter retinal detachment, and its masquerade as a persistent postoperat
ive uveitis.