TRANSARTERIAL WALL OXYGEN GRADIENTS AT THE DOG CAROTID BIFURCATION

Citation
Sm. Santilli et al., TRANSARTERIAL WALL OXYGEN GRADIENTS AT THE DOG CAROTID BIFURCATION, American journal of physiology. Heart and circulatory physiology, 37(1), 1995, pp. 155-161
Citations number
29
Categorie Soggetti
Physiology
ISSN journal
03636135
Volume
37
Issue
1
Year of publication
1995
Pages
155 - 161
Database
ISI
SICI code
0363-6135(1995)37:1<155:TWOGAT>2.0.ZU;2-V
Abstract
The purpose of this study was to determine the effect of the carotid a rtery bifurcation on the delivery of oxygen to the artery wall by meas uring the transarterial wall oxygen gradient. Transarterial wall oxyge n gradient measurements were performed in dogs anesthetized with thiop ental sodium and isoflurane by means of an oxygen microelectrode. Meas urements were performed at six locations along the carotid bifurcation . Oxygen tensions at the carotid sinus were decreased in the inner 40% of the artery wall compared with control locations. Oxygen tensions a t the flow divider were increased throughout the artery wall compared with control locations. These effects were noted without differences i n blood pressure, arterial blood oxygen tension, or histological evide nce of atherosclerotic lesion formation. These findings suggest that t he delivery of oxygen to the artery wall is altered by the bifurcation of the carotid artery. Low arterial oxygen tensions at the carotid si nus support a role for artery wall hypoxia in the formation of atheros clerotic lesions.