INHIBITION OF CARDIAC SARCOLEMMAL SODIUM-CALCIUM EXCHANGER BY GLYCEROPHOSPHOINOSITOL 4-PHOSPHATE AND GLYCEROPHOSPHOINOSITOL 4-5-BISPHOSPHATE

Authors
LUCIANI S ANTOLINI M BOVA S CARGNELLI G CUSINATO F DEBETTO P TREVISI L VAROTTO R
Citation
S. Luciani et al., INHIBITION OF CARDIAC SARCOLEMMAL SODIUM-CALCIUM EXCHANGER BY GLYCEROPHOSPHOINOSITOL 4-PHOSPHATE AND GLYCEROPHOSPHOINOSITOL 4-5-BISPHOSPHATE, Biochemical and biophysical research communications, 206(2), 1995, pp. 674-680
Citations number
20
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
206
Issue
2
Year of publication
1995
Pages
674 - 680
Database
ISI
SICI code
0006-291X(1995)206:2<674:IOCSSE>2.0.ZU;2-Z
Abstract
The enrichment in phosphatidylinositol 4-phosphate and phosphatidylino sitoI 4-5-bisphosphate of cardiac sarcolemmal vesicles stimulate Na+/C a2+ exchange activity. On the contrary the deacylation products of pol yphosphoinositides are powerful inhibitors of Na+/Ca2+ exchange: half maximal inhibition of 1.6 and 2.1 mu M have been observed for glycerop hosphoinositol 4-phosphate and glycerophosphoinositol 4-5-bisphosphate , respectively. The data indicate a bidirectional regulation of Na+/Ca 2+ exchanger and suggest that phosphorylated glycerophosphoinositoIs c an be regarded as novel signal transducers of intracellular Ca2+ regul ation in heart cell. (C) 1995 Academic, Inc.