L. Ostroskyzeichner et al., HUMORAL AND CELLULAR IMMUNE-RESPONSE WITHIN THE SUBARACHNOID SPACE OFPATIENTS WITH NEUROCYSTICERCOSIS, Archives of medical research, 27(4), 1996, pp. 513-517
To study the immune response within the subarachnoid space in patients
with neurocysticercosis, we measured the cerebrospinal fluid contents
of immunoglobulins A, E, G, and M in 38 patients and the contents of
the proinflammatory cytokines TNF-alpha, IL-1b, LC-6 and IFN-gamma in
17 patients. The same measurements were made in 30 neurological patien
ts without inflammatory or immune-mediated disorders. Each immunoglobu
lin and cytokine, including the gender and age of the patient, was com
pared by multiple regression analysis with the CSF contents of cells,
protein and ELISA for cysticercal antigens. A direct correlation was f
ound of IgM with cell content (p < 0.058) and with ELISA values (p < 0
.027); bf age with protein content (p < 0.006); of IL-6 with protein c
ontent (p < 0.018) and of IL-1b with ELISA values (p < 0.004). An inve
rse correlation was found of glucose with ELISA values (p < 0.008). A
complex function of the immune response within the subarachnoid space
was observed: mean values of IgG, IgM, IgE and interleukins Ib and 6 w
ere increased, whereas values of IgA, TNF-alpha and IFN-gamma were sim
ilar to those of controls.