DEEP CEREBRAL VENOUS THROMBOSIS AND HEREDITARY TISSUE-PLASMINOGEN ACTIVATOR (T-PA) DEFICIENCY

We describe a patient with defective tissue plasminogen activator (t-P A) release who developed internal cerebral vein thrombosis. She recove red completely and, as shown by MRI, favourable outcome was probably r elated to vascular recanalisation. Other members of the pedigree had a similar fibrinolytic deficiency without clinical manifestations. The use of oval contraceptives may have contributed to the patient's hyper coagulable state.