CURRENT EVALUATION OF LYMPHEDEMA AND ASSESSMENT BY LYMPHOSCINTIGRAPHYOF THE EFFECT OF A MICRONIZED FLAVONOID FRACTION (DAFLON-500-MG) IN THE TREATMENT OF UPPER-LIMB LYMPHEDEMA
Ap. Pecking et P. Rambert, CURRENT EVALUATION OF LYMPHEDEMA AND ASSESSMENT BY LYMPHOSCINTIGRAPHYOF THE EFFECT OF A MICRONIZED FLAVONOID FRACTION (DAFLON-500-MG) IN THE TREATMENT OF UPPER-LIMB LYMPHEDEMA, Phlebology, 9, 1994, pp. 26-29
Objective: To assess the effect of Daflon 500 mg on upper lymphoedema
occurring after conventional treatment of breast cancer. Design: Open,
pilot, single centre trial. Setting: Hospital outpatients attending a
University Hospital. Patients: Ten female patients (aged 44-64 years)
whose previous treatment for breast cancer was followed by upper limb
lymphoedema (mean (SD) time delay = 17 +/- 7 months). Interventions:
Oral administration of a daily dose of two tablets of Daflon 500 mg fo
r 6 months. Main outcome measures: Symptoms, affected upper limb volum
e and parameters of radionuclide lymphoscintigraphy using technetium-9
9m. Results: All patients experienced improvement of symptoms and limb
volume (mean volume decrease of the swollen limb: 6.80%). Functional
parameters assessed with scintigraphy were significantly improved (hal
f-life: 147.4 (14.9) to 144.1 (14.9) min, p < 0.01; clearance of the c
olloid: 25.9 (2.5) to 28.3 (2.8) mu l/min, p < 0.05; lymphatic speed o
f the colloid: 7.7 (0.3) to 8.0 (0.2) cm/min, p < 0.05). Conclusion: T
hese preliminary results suggest that this therapy is effective for th
e treatment of lymphoedema.