The appearance of blood in the seminal fluid is an alarming sign, with
a rather inconstant origin. The causes of hematospermia are discussed
based on a review of the literature and the authors' own experience w
ith 84 patients. The importance of differential diagnosis is emphasize
d and a diagnostic scheme is presented. Therapeutic opportunities depe
nding on etiology are discussed. It is concluded that although hematos
permia is an often self-limiting sign, resolving in a few weeks, all p
atients should undergo a careful investigation to rule out the presenc
e of malignancy or other significant disease.