EFFECT OF ACETAMINOPHEN ON GLUTATHIONE LEVELS IN RAT TESTIS AND LUNG

Glutathione (GSH) levels in rat testis and lung after oral administrat ion (3 g/kg) of acetaminophen (APAP) were studied. At the administered dose APAP is present in each organ and influences the GSH levels. APA P value of 114 mu g/g was obtained in testis at 6 hr (peak time); in t he lung the C-max was 92 mu/g at 8 hr and this value lasted several ho urs longer than that in testis. GSH levels are also affected different ly in the organs studied after APAP administration; the lungs seem to be the primary organ undergoing the depleting action of APAP this proc ess could not only cause toxicity, but also predispose those organs to the action of toxic compounds responsible for specific pathologies.