Objective-To determine whether the risk of the sudden infant death syn
drome is increased in bottle fed babies. Design-Population based case-
control study matching for age and time. Subjects-All babies aged 1 we
ek to 1 year dying of sudden infant death syndrome during November 198
7 to April 1989 or February 1990 to June 1991 and two live controls. S
etting-Avon and north Somerset. Main outcome measures-Breast or bottle
feeding, sleeping position, maternal smoking, parental employment, an
d length of gestation. Results-Compared with being fully breast fed, t
he crude odds ratio for sudden infant death in fully bottle fed babies
was 3.1 and for mixed breast and bottle fed babies 1.5. These odds ra
tios fell to 1.8 (95% confidence interval 0.7 to 4.8) and 1.2 (0.5 to
2.7) respectively after maternal smoking, parental employment, preterm
gestation, and sleeping position had been adjusted for. Sleeping posi
tion partly masked the effect of being bottle fed on sudden infant dea
th as breast fed babies were more likely to have slept prone than bott
le fed babies. Conclusions-Bottle feeding is not a significant indepen
dent risk factor for the sudden infant death syndrome. Patterns of mat
ernal smoking, preterm gestation, and parental employment status accou
nt for most of the apparent association with bottle feeding.