A GUIDELINE SUPPLEMENT FOR DETERMINING THE AQUATIC TOXICITY OF POORLYWATER-SOLUBLE COMPLEX-MIXTURES USING WATER-ACCOMMODATED FRACTIONS

Regulatory guideline methods for aquatic toxicity testing have general ly been developed for pure chemicals tested at concentrations below th e limit of their water solubility where exposure concentration can be quantified in terms of a concentration in solution. The same methods m ay also be applied to testing products which are complex chemical mixt ures at product:water ratios that do not exceed the water-solubility o f any of the product components. A different approach is required for testing complex mixtures at ratios which exceed water-solubilities of some of the components.