EFFECTS OF CIS-DICHLORODIAMMINEPLATINUM ON THE MOLECULAR LAYER INTERNEURONS OF THE IMMATURE RAT CEREBELLUM - A PUTATIVE ROLE FOR CALCIUM

Authors
NECCHI D SCHERINI E LUCHINI G BERNOCCHI G
Citation
D. Necchi et al., EFFECTS OF CIS-DICHLORODIAMMINEPLATINUM ON THE MOLECULAR LAYER INTERNEURONS OF THE IMMATURE RAT CEREBELLUM - A PUTATIVE ROLE FOR CALCIUM, European journal of morphology, 33(1), 1995, pp. 81-89
Citations number
18
Categorie Soggetti
Anatomy & Morphology
Journal title
European journal of morphology → ACNP
ISSN journal
09243860
Volume
33
Issue
1
Year of publication
1995
Pages
81 - 89
Database
ISI
SICI code
0924-3860(1995)33:1<81:EOCOTM>2.0.ZU;2-W
Abstract
The administration of cis-dichlorodiammineplatinum to rats at 10 days of postnatal life (PD 10) alters the immunoreactivity for parvalbumin of the interneurons of the cerebellar molecular layer at late post-tre atment intervals. This can result in, but may be also a consequence of the elevation in the cytosolic calcium concentration. Changes in the intracellular calcium homeostasis may induce damage of the cytoskeleta l apparatus and impair growth of the cell processes leading to alterat ion of the ultrastructure of the cell.