CHIRAL BETA-LACTAMS AS SYNTHONS - STEREOSPECIFIC SYNTHESIS OF A 6-EPI-LINCOSAMINE DERIVATIVE

Authors
BOSE AK MATHUR C WAGLE DR NAQVI R MANHAS MS URBANCZYKLIPKOWSKA Z
Citation
Ak. Bose et al., CHIRAL BETA-LACTAMS AS SYNTHONS - STEREOSPECIFIC SYNTHESIS OF A 6-EPI-LINCOSAMINE DERIVATIVE, Heterocycles, 39(2), 1994, pp. 491-496
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
39
Issue
2
Year of publication
1994
Pages
491 - 496
Database
ISI
SICI code
0385-5414(1994)39:2<491:CBAS-S>2.0.ZU;2-H
Abstract
A derivative of 6-epi-lincosamine has been prepared by a sequence of s tereospecific steps from an optically active, cis-alpha-hydroxy-beta-l actam. This beta-lactam was obtained by an enantiospecific cycloadditi on reaction between methoxyacetyl chloride, triethylamine and a Schiff base derived from benzylamine and an optically active aldehyde derive d from D-galactopyranose.