A CONVENIENT SYNTHESIS OF A SIMPLE COUMARIN FROM SALICYLALDEHYDE AND WITTIG REAGENT .1. A SYNTHESIS OF METHOXYCOUMARIN AND HYDROXYCOUMARIN

Authors
HARAYAMA T KATSUNO K NISHIOKA H FUJII M NISHITA Y ISHII H KANEKO Y
Citation
T. Harayama et al., A CONVENIENT SYNTHESIS OF A SIMPLE COUMARIN FROM SALICYLALDEHYDE AND WITTIG REAGENT .1. A SYNTHESIS OF METHOXYCOUMARIN AND HYDROXYCOUMARIN, Heterocycles, 39(2), 1994, pp. 613-622
Citations number
40
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
39
Issue
2
Year of publication
1994
Pages
613 - 622
Database
ISI
SICI code
0385-5414(1994)39:2<613:ACSOAS>2.0.ZU;2-J
Abstract
Reaction of methoxy- and hydroxysalicylaldehydes (1) with phosphorane in diethylaniline under reflux gave only coumarins (3) in high yields except for 3-methoxysalicylaldehyde (1b). It was clarified that methox y group(s) at C-4 and C-6 on 1 facilitated the formation of 3.