Jp. Woods et al., CONCURRENT LYMPHANGIOMA, IMMUNE-MEDIATED THROMBOCYTOPENIA, AND VON WILLEBRANDS DISEASE IN A DOG, The Journal of the American Animal Hospital Association, 31(1), 1995, pp. 70-76
Lymphangioma, immune-mediated thrombocytopenia (IMT), and von Willebra
nd's disease (vWD) were diagnosed by histology, hematology, and a coag
ulation profile in a 14-month-old, female dachshund. Clinical and labo
ratory findings included ecchymotic inguinolabial swelling, thrombocyt
openia, positive platelet factor-3 assay, prolonged buccal mucosal ble
eding time, and subnormal von Willebrand factor antigen concentration
and factor VIII activity. The IMT resolved with immunosuppressive gluc
ocorticoid therapy Histologic examination identified lymphangioma whic
h was too extensive for surgical excision. The history and the clinica
l and laboratory findings were consistent with congenital vWD, althoug
h acquired vWD secondary to lymphangioma could not be ruled out.