EVALUATION OF THE LABORATORY MOUSE MODEL FOR SCREENING TOPICAL MOSQUITO REPELLENTS

Eight commercial repellents were tested against Aedes aegypti 0 and 4 h after application in serial dilution to volunteers and laboratory mi ce. Results were analyzed by multiple regression of percentage of biti ng (probit scale) on dose (logarithmic scale) and time. Empirical corr ection terms for conversion of values obtained in tests on mice to val ues expected in tests on human volunteers were calculated from data ob tained on 4 repellents and evaluated with data obtained on 4 others. C orrected values from tests on mice did not differ significantly from v alues obtained in tests on volunteers. Test materials used in the stud y were dimethyl phthalate, butopyronoxyl, butoxy polypropylene glycol, MGK Repellent 11(R), deet, ethyl hexanediol, Citronyl(R), and dibutyl phthalate.