ATRIAL-NATRIURETIC-PEPTIDE INHIBITED THE NATRIFERIC AND HYDROSMOTIC EFFECTS OF ARGININE VASOTOCIN ON TOAD SKIN

Authors
BERMAN DM SORIA MO DEGRIFASI MP COVIELLO A
Citation
Dm. Berman et al., ATRIAL-NATRIURETIC-PEPTIDE INHIBITED THE NATRIFERIC AND HYDROSMOTIC EFFECTS OF ARGININE VASOTOCIN ON TOAD SKIN, Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 109(3), 1994, pp. 277-282
Citations number
27
Journal title
Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology → ACNP
ISSN journal
13678280
Volume
109
Issue
3
Year of publication
1994
Pages
277 - 282
Database
ISI
SICI code
1367-8280(1994)109:3<277:AITNAH>2.0.ZU;2-3
Abstract
The effect of rat atrial natriuretic peptide (rANP) on hormonal stimul ated osmotic water permeability (Jw, hydrosmotic effect) and net ion t ransport (short-circuit current, SCC, natriferic effect) was studied o n toad skin, a tissue with functional similarities to the mammalian di stal nephron, in order to assess actions on transport mechanisms. Rat atrial natriuretic peptide, rANP-99-126 (rANP) inhibited stimulated SC C and Jw to submaximal concentrations of arginine vasotocin (AVT) at a site before cyclic AMP generation. The angiotensin-converting enzyme inhibitor (ACEI) MK-422 did not modify the inhibitory effect of ANP in the stimulated Jw.