ACTIVITY OF SOME MANNICH-BASES OF CONJUGATED STYRYL KETONES AGAINST CANDIDA-ALBICANS

A number of Mannich bases of conjugated styryl ketones displayed activ ity against Candida albicans strains 3153A and B311. Antifungal potenc y was influenced by the relative hydrophobicities of the molecules and on occasions by the electronic nature of the aryl substituents. The c ompounds inhibited one or more of the following enzymes in the glutath ione metabolic pathway namely glutathione S-transferases, glutathione reductase, gamma-glutamyl transpeptidase and glutathione peroxidase. N early half of the compounds examined on the yeast-to-mycelium transiti on in C. albicans 3153A prevented this conversion from occuring.