MICROANGIOPATHIC HEMOLYTIC-ANEMIA AND SEVERE THROMBOCYTOPENIA IN BRUCELLA INFECTION

A case of Brucella septicemia presenting at the onset as a severe micr oangiopathic hemolytic anemia with coexisting dramatic hemorrhagic syn drome (severe epistaxis, gross hematuria, and skin purpura) is reporte d. A hemogram showed severe thrombocytopenia, anemia, and leukopenia. Bone marrow morphology showed the typical features associated with Bru cella infection: numerous histiocytes with signs of activation, multip le granulomata, giant cells, and hemophagocytosis. After appropriate a ntimicrobial therapy, the clinical and hematological status of the pat ient improved, and he is alive and well 1 year later with disappearanc e of all hematological abnormalities.