LACTONES .28. EPC-SYNTHESIS, STRUCTURE AN D PHARMACOLOGY OF LACTONIZED AND LACTAMIZED ANALOGS OF ACETYLCHOLINE

Authors
PIEPER B TRANKLE C NIEGER M MOHR K LEHMANN J
Citation
B. Pieper et al., LACTONES .28. EPC-SYNTHESIS, STRUCTURE AN D PHARMACOLOGY OF LACTONIZED AND LACTAMIZED ANALOGS OF ACETYLCHOLINE, Die Pharmazie, 50(1), 1995, pp. 15-21
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
50
Issue
1
Year of publication
1995
Pages
15 - 21
Database
ISI
SICI code
0031-7144(1995)50:1<15:L.ESAD>2.0.ZU;2-O
Abstract
The enantiopure gamma-aminomethyl-gamma-butyrolactones (S)- and (R)-4a -d represent constrained analogues of acetylcholine, which were synthe sized from D- or L-glutamic acid following two different routes. In ad dition, the corresponding lactames (S)- and (R)-10 were prepared by en antioselective synthesis. Only moderate activity was found at acetylch oline sites at the guinea pig atrium.