SPIN-LABELED AMINO-ACID NITROSOUREA DERIVATIVES - SYNTHESIS AND ANTITUMOR-ACTIVITY

Authors
ZHELEVA A RAIKOV Z ILARIONOVA M TODOROV D
Citation
A. Zheleva et al., SPIN-LABELED AMINO-ACID NITROSOUREA DERIVATIVES - SYNTHESIS AND ANTITUMOR-ACTIVITY, Die Pharmazie, 50(1), 1995, pp. 25-26
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
50
Issue
1
Year of publication
1995
Pages
25 - 26
Database
ISI
SICI code
0031-7144(1995)50:1<25:SAND-S>2.0.ZU;2-K
Abstract
The synthesis of three spin labeled derivatives of N-[N'-(2-chloroethy l)-N'-nitrosocarbamoyl] amino acids is reported, The new nitrosoureas are obtained by condensation of the corresponding N-[N'-(2-chloroethyl )-N'-nitrosocarbamoyl] amino acid with 2,2,6,6-tetramethyl-1-oxyl-4-am inopiperidine using dicyclohexylcarbodiimide. Their chemical structure s are confirmed by elemental analysis, IR, MS, and EPR spectroscopy, A ll newly synthesized compounds showed high antitumour activity against the lymphoid leukemia L1210 in BDF1 mice.