THE INFLUENCE OF GLYCOAMINES FROM THE BLO OD-SERUM AND SYNTHETIC ANALOGS ON AGGREGATIONAL PROPERTIES OF HUMAN THYROID-GLAND CANCER-CELLS

This study explored the influence of glycoaminoconjugates (glycoamines ) from blood serum and synthetic analogues on aggregational and migrat ional properties of human thyroid gland cancer cells. The data present ed suggest that glycoamines and synthetic analoges suppress the growth of cancer bioptates, formation aggregates by tumor cells in suspensio nal culture and enhance adhesion of these cells to hard substrate. The surface carbohydrate determinants of thyroid glang cancer cells have been examined. The glycoaminoconjugates significantly blocked the lect in-like activities on the surface of tumor cells. It is supposed that masking of lectin-like structures of cell surface by glycoamines may d ecrease aggregation and migration of tumor cells.