IMMUNOPHENOTYPING OF BLAST CELLS IN PATIE NTS WITH CHRONIC MYELOLEUKEMIA AT THE STAGE OF BLAST CRISIS AND DETERMINATION OF ITS IMMUNOLOGICAL VARIANTS

Immunologic phenotype of blast cells has been investigated in 45 patie nts with chronic myelo leukemia at the stage of blast crisis (BC CLM). The patients were divided into groups depending on the immunologic ph enotype of blast cells from peripheral blood: 5 patients - primitive v ariant, 19 - mixed variant, 3 - lymphoid, 12 - myeloid and 1 - erithro id variant. In patients with primitive variant blast cells possessed t he markers of hemopoietic stem cell. In patients with mixed variant bl ast cells had the signs of myeloid and lymphoid differentiation. In pa tients with lymphoid variant blast cells with lymphoblast phenotype we re revealed. Typical myeloblasts were found out in patients with myelo id variant. Blast cells from the patients with erithroid variant posse ssed typical markers of erythroblasts. When carrying out the analysis of immunologic phenotype of blast cells from patients in dynamics one can note the conditional character of the selection of patiens' groups since immunologic phenotype of blast cells has been altered in 37 per cent of patients within 1 month, it being an evidence for the changin g of circulating pool of blast cells. The notion about the rightful se lection of immunologic variants of BC CML is discussed.