EFFECT OF COORDINATION-COMPOUNDS OF ZINC ON THE ACTIVITY OF ORNITHINEDECARBOXYLASE, SOME PARAMETERS OF NUCLEAR CHROMATIN AND GROWTH OF TRANSPLANTABLE TUMORS IN MICE

There was been studied the effect of co-ordinating Zn compounds contai ning various number of amines and other agents in co-ordination sphere on some indices of tumor cell metabolism and the growth of transplant able tumors in mice. These compaunds were shown to inhibit ornithindec arboxylase activity to different extent, to increase ribonuclease acti vity and to alter the firmness of DNA-protein bonds in nuclear chromat in of tumor cells. These compounds exert toxic effect on tumor cells a t the concentration of 10(-5)-10(-6) M which is displayed to various e xtent depending on the compound structure. The correlation was establi shed between the degree of biochemical changes in tumor cells and the intensity of antitumor effect of compound.