The radioimmunological method was used to determine the content of tum
or markers APP, REA, CA 19-9, and CA 72-4 in 53 patients with nonmalig
nant three-dimentional structures in the liver (hemangioma, nonparasit
ic cysts, alveococcosis, hydatid cycts), in 9 patients with primary ca
rcinoma of the liver, and in 24 healthy individuals. The significance
of APP determination and complex study of tumor markers in the recogni
tion and differential diagnosis of benign and malignant structures in
the liver is shown. It allowed the percentage of disparity between the
laboratory and the verified diagnosis to be reduced to 4.8%.