PURPOSE: This report presents a patient who developed signs and sympto
ms of acute appendicitis because of sarcoid involvement of the appendi
x. METHODS: This is a retrospective case review with review of the Eng
lish language literature. RESULTS: The patient underwent appendectomy
for suspected acute appendicitis. Histologically the appendix had no s
igns of acute inflammation but did have noncaseating granulomas. The p
atient's abdominal pain resolved following appendectomy, and she has h
ad no further similar pain in the two years since the operation. CONCL
USION: Patients with sarcoidosis may develop signs and symptoms of acu
te appendicitis without inflammation. Operative exploration should not
be delayed in equivocal cases of right lower quadrant abdominal pain
in patients with sarcoidosis.